Name: The Clinical Puzzle of Anaerobic Bacteremia: Unpacking Traits of Infections and Patients with Anaerobic Bloodstream Infections and Impact of Adequate Treatment
Start: 2025-04-25T09:30:00-0400
End: 2025-04-25T09:45:00-0400

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Friday April 25, 2025 9:30am - 9:45am EDT

Parthenon 2

Title: The Clinical Puzzle of Anaerobic Bacteremia: Unpacking Traits of Infections and Patients with Anaerobic Bloodstream Infections and Impact of Adequate Treatment
Authors: Sonjala Mallory, James Holland, Tyler Martin, Geren Thomas

Background: Anaerobic bloodstream infections (BSIs) are rare but clinically significant, with mortality rates ranging from 15% to 55%. These infections are commonly associated with immunosuppression, malignancies, and surgical interventions. The most frequent causative pathogens include Bacteroides spp., Clostridium spp., and Fusobacterium spp., with increasing resistance complicating treatment. Distinguishing true infections from contaminants, particularly Cutibacterium spp., remains a diagnostic challenge. This study aims to characterize anaerobic BSIs, identify factors distinguishing true infections from contamination, and assess the impact of timely and appropriate antibiotic therapy on patient outcomes.

Methods: This retrospective, cross-sectional study was conducted at a teaching hospital from January 2019 to April 2024. Sixty patients with confirmed anaerobic bloodstream infections were included. Patient demographics, source of infection, and clinical severity (PITT Bacteremia Score) were collected. Microbiological data, including blood culture results, were used to determine antibiotic adequacy. Patients were divided into two groups based on whether they received adequate or inadequate antibiotic therapy. Outcomes of interest include infection resolution, length of hospital stay, and 30-day all-cause in-hospital mortality. The correlation between appropriate indication documentation and antibiotic selection was evaluated. Descriptive statistics were used to summarize characteristics, and correlations between treatment adequacy, documentation, and outcomes were explored.

Results: In-Progress

Conclusion: In-Progress

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