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Assessment of Biomarker Testing in Hormone Receptor-Positive and Human Epidermal Growth Factor 2 Receptor-Negative Breast Cancer Patients
Thursday April 24, 2025 12:00pm - 12:15pm EDT
Olympia 2
Title: Assessment of Biomarker Testing in Hormone Receptor-Positive and Human Epidermal Growth Factor 2 Receptor-Negative Breast Cancer Patients 
Authors: Sarah Seward, Thomas Morris, Alexia Greene 
Background: Biomarkers are molecules within the body used to guide treatment of diseases. Genetic biomarkers can help predict the response to cancer therapy. Studies have shown inadequate utilization of biomarker testing despite high prevalence of mutations and significant improvements in clinical outcomes with targeted therapy. Previous literature supports the use of biomarker testing based on improved patient outcomes and suggests the need for improvement in routine clinical testing. The aim of this study is to assess the utilization of biomarker testing in accordance with guideline recommendations for ESR1, AKT1, PIK3CA, and BRCA mutations in endocrine-resistant metastatic breast cancer patients.   
Methods: This study was a retrospective, observational, cohort study utilizing electronic medical records. Data collection included FirstHealth Cancer Center patients between January 1st, 2023, and December 31st, 2023. Patients were included by the following criteria: 18 years of age or older, female, and with HR+, HER2- metastatic breast cancer. Exclusion criteria include
Moderators
avatar for Sheema Hallaji

Sheema Hallaji

PGY1 Residency Director, Cone Health- Alamance Regional Medical Center
Presenters
avatar for Sarah Seward

Sarah Seward

PGY1 Acute Care Pharmacy Resident, FirstHealth Moore Regional Hospital
Sarah Seward, PharmD, is originally from Northeastern Pennsylvania, where she graduated from Wilkes University Nesbitt School of Pharmacy. She is currently a PGY1 Acute Care resident at FirstHealth of the Carolinas in Pinehurst, NC. Sarah will be continuing her career as a PGY2 Critical... Read More →
Evaluators
EO
Thursday April 24, 2025 12:00pm - 12:15pm EDT
Olympia 2
  Oncology (ONC), FirstHealth Moore Regional Hospital
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